Have you ever taken Nexium, Prilosec or many other stomach acid-reducing drugs? Chances are, you or someone you know has. They are among the most widely prescribed drugs in the U.S.
But these drugs can cause long-term dependence and should carry the strongest possible warning label for a variety of dangerous adverse effects, Public Citizen told the U.S. Food and Drug Administration (FDA) in a petition sent today.
The drugs are proton pump inhibitors (PPIs), so-named because of the mechanism they use to shut off the production of stomach acid. An estimated 119 million prescriptions dispensed in 2009 and $13.6 billion in U.S. sales. About 1 of every 20 people in the developed world is taking the medications, which include Nexium, Dexilant, Prilosec, Prilosec OTC, Zegerid, Zegerid OTC, Prevacid, Prevacid 24-Hr, Protonix, Aciphex, Vimovo and numerous generic counterparts, most prominently omeprazole and pantoprazole.
Said Dr. Sidney Wolfe, director of Public Citizen’s Health Research Group:
These drugs are being prescribed far too commonly to people who shouldn’t be taking them. As a result, millions of people are needlessly setting themselves up to become dependent on PPIs while exposing themselves to the serious risks associated with long-term therapy. The FDA should act immediately to ensure that patients and physicians are adequately warned of these effects, and reminded of the many safer alternatives for common conditions such as acid reflux.
PPIs are approved to treat gastroesophageal reflux disease (GERD) – sometimes referred to as acid reflux – as well as gastric ulcers, erosive esophagitis and stomach bleeding associated with using non-steroidal anti-inflammatory drugs (NSAIDs). But evidence shows that after using PPIs for a month or more, patients who stop taking the drug make even more stomach acid than before they started the drug, a phenomenon known as rebound acid hypersecretion, which causes acid reflux symptoms to return even worse than before therapy.














